Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response

Table 1 Summary of key demographics of matched groups

	Control	AD	Resilient	P
N	12	12	11
Sex	6M/6F	6M/6F	6M/5F	0.895
Age	82.2 ± 10.6	82.0 ± 9.6	87.7 ± 8.2	0.280
pH	6.6 ± 0.3	6.5 ± 0.3	6.4 ± 0.2	0.393
PMI	6.0 ± 1.8	5.1 ± 1.0	6.4 ± 1.7	0.141
CDR/GDS	≤ 0.5/1–2	= 3/7	≤ 0.5/1–2
ApoE-ε4	3+/9−	7+/5−	5+/6−	0.251
RIN	8.0 ± 0.8	8.1 ± 0.8	7.4 ± 0.6	0.066
BW	1162.8 ± 119.9	1088.7 ± 135.0	1196.4 ± 102.5	0.103
CERAD	0.1 ± 0.3	2.6 ± 0.7	1.7 ± 0.8	< 0.0001
Braak	1.3 ± 0.7	5.5 ± 0.8	4.3 ± 0.9	< 0.0001
Thal	0.7 ± 0.7	4.7 ± 0.8	3.5 ± 0.5	< 0.0001
TDP-43 (NC-LATE)	0	0	0.1	0.336
α-syn	0	0	0
HS	0	1	0	0.358
Vascular pathology	0	2	1	0.326

AD Alzheimer’s disease, α-syn α-synuclein, ApoE-ε4 Apolipoprotein E4 allele, BW brain weight (grams), CERAD Consortium to Establish a Registry for Alzheimer's Disease, CDR Clinical Dementia Rating, F female, GDS Global Deterioration Scale, HS hippocampal sclerosis, M male, PMI post-mortem interval (hours), RIN RNA integrity number, TDP-43 (LATE-NC) TAR DNA-binding protein 43, Limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes
P = ANOVA-based P-value for continues variables and chi-square based P-values for categorical values. Data are represented as mean ± SD

ISSN: 2051-5960