From: Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
N | No tau pathology: AD-tau ( −), AGD-tau ( −) | AD-tau pathology only AD-tau ( +), AGD-tau ( −) | Mixed tauopathy AD-tau (+ / −), AGD-tau ( +) | APOE x tau pathology interaction | ||||
---|---|---|---|---|---|---|---|---|
β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | Interaction p-value | ||
APOE2 vs. APOE3 (reference) | APOE2 (N = 21) vs APOE3 (N = 73) | APOE2 (N = 13) vs APOE3 (N = 54) | APOE2 (N = 11) vs APOE3 (N = 27) | |||||
Aβ40-TBS | 174 | 0.90 (− 0.20 to 1.99) | 0.11 | 0.12 (− 1.26 to 1.49) | 0.86 | − 0.72 (− 2.08–0.63) | 0.28 | 0.45 |
Aβ40-TBSX | 188 | 0.27 (− 0.51 to 1.05) | 0.49 | − 0.32 (− 1.41 to 0.77) | 0.56 | − 0.94 (− 1.80, 0.08) | 0.034 | 0.14 |
Aβ40-FA | 188 | 1.47 (− 3.72 to 6.67) | 0.57 | 1.16 (− 7.28 to 9.61) | 0.78 | 3.05 (− 2.25 to 8.34) | 0.25 | 0.95 |
Aβ42-TBS | 186 | 0.09 (− 1.38 to 1.56) | 0.90 | 1.52 (− 0.73 to 3.76) | 0.18 | 0.42 (− 1.86 to 2.70) | 0.71 | 0.60 |
Aβ42-TBSX | 192 | − 0.19 (− 1.45 to 1.07) | 0.77 | 0.00 (− 1.84 to 1.84) | 1.00 | − 2.47 (− 4.64, 0.30) | 0.027 | 0.11 |
Aβ42-FA | 197 | 1.86 (− 12.81 to 16.52) | 0.80 | 6.19 (− 11.78 to 24.17) | 0.49 | − 3.16 (− 25.26 to 18.93) | 0.77 | 0.77 |
apoE-TBS | 196 | 0.52 (0.02 to 1.03) | 0.042 | 0.56 (− 0.02 to 1.15) | 0.059 | 0.75 (0.18to 1.32) | 0.012 | 0.90 |
apoE-TBSX | 194 | − 0.04 (− 0.27 to 0.18) | 0.70 | − 0.17 (− 0.43 to 0.08) | 0.18 | − 0.19 (− 0.52 to 0.14) | 0.26 | 0.64 |
apoE-FA | 197 | 0.17 (− 0.59 to 0.93) | 0.66 | 0.06 (− 0.88 to 1.00) | 0.90 | 0.07 (− 0.81 to 0.95) | 0.87 | 0.89 |
tTau-TBS | 176 | − 7.27 (-14.55, 0.00) | 0.050 | 3.50 (-6.45 to 13.44) | 0.48 | − 1.75 (− 12.13 to 8.64) | 0.73 | 0.18 |
tTau-TBSX | 194 | − 0.05 (− 0.25 to 0.16) | 0.67 | 0.08 (− 0.24 to 0.39) | 0.63 | − 0.19 (− 0.46 to 0.09) | 0.18 | 0.51 |
tTau-FA | 201 | − 0.05 (− 0.30 to 0.20) | 0.69 | 0.35 (0.10 to 0.60) | 0.007 | 0.25 (− 0.06 to 0.55) | 0.11 | 0.061 |
pTau181-TBS | 194 | − 0.01 (− 0.25 to 0.22) | 0.92 | − 0.08 (− 0.41 to 0.24) | 0.61 | − 0.34 (− 0.72 to 0.04) | 0.075 | 0.23 |
pTau181-TBSX | 194 | − 0.19 (− 0.38 to 0.01) | 0.058 | 0.10 (− 0.10 to 0.31) | 0.32 | − 0.20 (− 0.46 to 0.06) | 0.13 | 0.10 |
pTau181-FA | 192 | − 0.24 (− 0.44, 0.03) | 0.023 | 0.46 (− 0.18 to 1.10) | 0.15 | 0.24 (− 0.14 to 0.62) | 0.21 | 0.065 |
APOE4 vs. APOE3 (reference) | APOE4 (N = 20) vs APOE3 (N = 73) | APOE4 (N = 115) vs APOE3 (N = 54) | APOE4 (N = 13) vs APOE3 (N = 27) | |||||
Aβ40-TBS | 267 | 0.48 (− 0.52 to 1.49) | 0.34 | 0.85 (− 0.07 to 1.77) | 0.069 | − 0.63 (− 1.98 to 0.71) | 0.34 | 0.50 |
Aβ40-TBSX | 292 | 0.12 (− 0.68 to 0.93) | 0.76 | 1.31 (0.51 to 2.11) | 0.002 | − 0.14 (− 0.74 to 0.47) | 0.65 | 0.049 |
Aβ40-FA | 290 | 7.21 (− 0.05 to 14.48) | 0.052 | 14.15 (7.47 to 20.83) | < 0.001 | 1.44 (− 3.49 to 6.37) | 0.56 | 0.088 |
Aβ42-TBS | 289 | 2.68 (1.34 to 4.02) | < 0.001 | 1.08 (0.19 to 1.96) | 0.017 | 2.09 (− 0.13 to 4.32) | 0.064 | 0.11 |
Aβ42-TBSX | 293 | 2.18 (0.80 to 3.57) | 0.002 | 1.07 (0.36 to 1.79) | 0.004 | 2.98 (0.99 to 4.97) | 0.004 | 0.10 |
Aβ42-FA | 303 | 21.79 (6.52 to 37.07) | 0.006 | 9.15 (1.22 to 17.07) | 0.024 | 26.52 (7.49 to 45.55) | 0.008 | 0.16 |
apoE-TBS | 303 | − 0.29 (− 0.80 to 0.22) | 0.26 | − 0.33 (− 0.65, 0.02) | 0.036 | 0.27 (− 0.25 to 0.79) | 0.30 | 0.32 |
apoE-TBSX | 296 | − 0.03 (− 0.28 to 0.22) | 0.82 | 0.22 (0.08 to 0.36) | 0.002 | 0.02 (− 0.27 to 0.31) | 0.89 | 0.087 |
apoE-FA | 302 | 0.31 (− 0.46 to 1.08) | 0.43 | 1.41 (0.82 to 2.01) | < 0.001 | 0.91 (− 0.15 to 1.96) | 0.091 | 0.085 |
tTau-TBS | 278 | − 0.34 (− 7.37 to 6.69) | 0.92 | 1.01 (− 4.32 to 6.34) | 0.71 | − 1.23 (− 10.56 to 8.09) | 0.79 | 0.85 |
tTau-TBSX | 296 | 0.01 (− 0.21 to 0.23) | 0.91 | − 0.09 (− 0.26 to 0.07) | 0.25 | 0.05 (− 0.23 to 0.33) | 0.71 | 0.76 |
tTau-FA | 308 | 0.02 (− 0.23 to 0.27) | 0.89 | − 0.09 (− 0.23 to 0.05) | 0.19 | − 0.08 (− 0.38 to 0.22) | 0.60 | 0.76 |
pTau181-TBS | 297 | − 0.11 (− 0.36 to 0.13) | 0.37 | − 0.03 (− 0.20 to 0.15) | 0.77 | − 0.18 (− 0.42 to 0.07) | 0.16 | 0.79 |
pTau181-TBSX | 295 | − 0.23 (− 0.44, 0.03) | 0.024 | 0.09 (− 0.02 to 0.21) | 0.10 | − 0.22 (− 0.44 to 0.00) | 0.052 | 0.004 |
pTau181-FA | 296 | 0.18 (− 0.04–0.40) | 0.12 | 0.60 (0.24 to 0.97) | 0.001 | 0.04 (− 0.33 to 0.40) | 0.85 | 0.067 |