From: Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
Variable | N | Unadjusted analysis | Adjusting for age and sex | Full multivariable analysis | |||
---|---|---|---|---|---|---|---|
β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | ||
Association with Aβ40-FA | |||||||
Age | 333 | − 2.58 (− 5.02, − 0.14) | 0.038 | − 2.45 (− 4.95, 0.06) | 0.056 | 0.60 (− 1.64, 2.83) | 0.60 |
Sex | 333 | 1.79 (− 2.06, 5.64) | 0.36 | 0.91 (− 3.03, 4.85) | 0.65 | − 0.62 (− 4.07, 2.83) | 0.72 |
APOE4 | 333 | 14.02 (10.43, 17.60) | < 0.001 | 13.87 (10.15, 17.59) | < 0.001 | 8.78 (4.93, 12.62) | < 0.001 |
VaD | 333 | − 1.43 (− 5.46, 2.60) | 0.49 | − 0.98 (− 5.06, 3.11) | 0.64 | − 0.41 (− 3.98, 3.16) | 0.82 |
CAA | 333 | 22.92 (15.89, 29.96) | < 0.001 | 22.76 (15.67, 29.84) | < 0.001 | 20.94 (14.49, 27.40) | < 0.001 |
Neuritic plaque score | 333 | 6.05 (4.53, 7.57) | < 0.001 | 5.97 (4.43, 7.52) | < 0.001 | 2.67 (0.62, 4.71) | 0.011 |
TDP-43 | 333 | 0.44 (− 6.88, 7.76) | 0.91 | 0.82 (− 6.51, 8.15) | 0.83 | − 3.81 (− 10.17, 2.55) | 0.24 |
Synuclein | 333 | 5.54 (1.08, 9.99) | 0.015 | 4.80 (0.27, 9.33) | 0.038 | 0.17 (− 3.85, 4.19) | 0.93 |
AD-tau | 327 | 12.48 (8.77, 16.19) | < 0.001 | 12.23 (8.46, 16.01) | < 0.001 | 4.39 (− 0.28, 9.06) | 0.065 |
AGD-tau | 333 | − 7.71 (− 13.13, − 2.28) | 0.006 | − 7.02 (− 12.52, − 1.52) | 0.012 | − 2.40 (− 7.28, 2.49) | 0.33 |
Association with Aβ42-FA | |||||||
Age | 348 | − 4.10 (− 8.31, 0.12) | 0.057 | − 4.15 (− 8.50, 0.20) | 0.062 | 2.71 (− 0.70, 6.11) | 0.12 |
Sex | 348 | 1.25 (− 5.53, 8.03) | 0.72 | − 0.34 (− 7.30, 6.61) | 0.92 | 1.47 (− 3.80, 6.73) | 0.58 |
APOE4 | 348 | 25.05 (18.75, 31.36) | < 0.001 | 25.30 (18.69, 31.90) | < 0.001 | 7.60 (1.68, 13.53) | 0.012 |
VaD | 348 | − 0.66 (− 7.78, 6.45) | 0.86 | 0.46 (− 6.77, 7.68) | 0.90 | 3.48 (− 1.99, 8.95) | 0.21 |
CAA | 348 | 20.19 (6.72, 33.66) | 0.003 | 19.91 (6.34, 33.47) | 0.004 | 14.11 (3.86, 24.35) | 0.007 |
Neuritic plaque score | 348 | 18.06 (15.85, 20.27) | < 0.001 | 18.31 (16.05, 20.57) | < 0.001 | 13.03 (9.93, 16.13) | < 0.001 |
TDP-43 | 348 | 11.83 (− 0.77, 24.44) | 0.066 | 12.04 (− 0.60, 24.67) | 0.062 | 0.18 (− 9.42, 9.77) | 0.97 |
Synuclein | 348 | 11.02 (3.15, 18.88) | 0.006 | 9.97 (1.94, 18.00) | 0.015 | − 1.23 (− 7.39, 4.94) | 0.70 |
AD-tau | 342 | 35.46 (29.68, 41.25) | < 0.001 | 35.42 (29.50, 41.34) | < 0.001 | 12.27 (5.23, 19.31) | < 0.001 |
AGD-tau | 348 | − 19.91 (− 29.26, − 10.56) | < 0.001 | − 19.18 (− 28.66, − 9.70) | < 0.001 | − 3.81 (− 11.20, 3.58) | 0.31 |
Association with apoE-FA | |||||||
Age | 346 | − 0.53 (− 0.76, − 0.29) | < 0.001 | − 0.51 (− 0.75, − 0.27) | < 0.001 | − 0.25 (− 0.48, − 0.02) | 0.031 |
Sex | 346 | 0.30 (− 0.08, 0.69) | 0.12 | 0.12 (− 0.26, 0.51) | 0.53 | 0.14 (− 0.20, 0.49) | 0.42 |
APOE4 | 346 | 1.39 (1.03, 1.76) | < 0.001 | 1.25 (0.88, 1.63) | < 0.001 | 0.79 (0.39, 1.18) | < 0.001 |
VaD | 346 | − 0.36 (− 0.76, 0.05) | 0.082 | − 0.24 (− 0.64, 0.17) | 0.25 | − 0.09 (− 0.45, 0.28) | 0.63 |
CAA | 346 | 1.26 (0.51, 2.02) | 0.001 | 1.17 (0.43, 1.91) | 0.002 | 0.82 (0.15, 1.49) | 0.016 |
Neuritic plaque score | 346 | 0.74 (0.59, 0.89) | < 0.001 | 0.70 (0.55, 0.85) | < 0.001 | 0.65 (0.44, 0.85) | < 0.001 |
TDP-43 | 346 | 0.43 (− 0.30, 1.17) | 0.25 | 0.51 (− 0.21, 1.23) | 0.16 | 0.04 (− 0.61, 0.69) | 0.91 |
Synuclein | 346 | 0.55 (0.09, 1.00) | 0.018 | 0.38 (− 0.07, 0.83) | 0.10 | − 0.15 (− 0.56, 0.26) | 0.47 |
AD-tau | 340 | 1.08 (0.70, 1.46) | < 0.001 | 0.96 (0.58, 1.34) | < 0.001 | − 0.30 (− 0.77, 0.16) | 0.20 |
AGD-tau | 346 | − 0.64 (− 1.19, − 0.10) | 0.021 | − 0.48 (− 1.03, 0.06) | 0.080 | 0.04 (− 0.45, 0.54) | 0.86 |
Association with tTau-FA | |||||||
Age | 353 | 0.03 (− 0.03, 0.09) | 0.29 | 0.03 (− 0.03, 0.09) | 0.37 | 0.00 (-0.07, 0.06) | 0.92 |
Sex | 353 | − 0.04 (− 0.14, 0.06) | 0.41 | − 0.03 (− 0.13, 0.07) | 0.56 | − 0.03 (− 0.13, 0.07) | 0.52 |
APOE4 | 353 | − 0.16 (− 0.26, − 0.06) | 0.001 | − 0.16 (− 0.26, − 0.05) | 0.003 | − 0.11 (− 0.22, 0.00) | 0.059 |
VaD | 353 | 0.01 (− 0.09, 0.12) | 0.79 | 0.01 (− 0.10, 0.11) | 0.88 | 0.02 (− 0.09, 0.12) | 0.74 |
CAA | 353 | − 0.06 (− 0.26, 0.13) | 0.52 | − 0.05 (− 0.25, 0.14) | 0.60 | − 0.05 (− 0.25, 0.14) | 0.61 |
Neuritic plaque score | 353 | − 0.04 (− 0.09, − 0.00) | 0.041 | − 0.04 (− 0.09, 0.00) | 0.055 | 0.01 (− 0.05, 0.06) | 0.82 |
TDP-43 | 353 | − 0.13 (− 0.32, 0.05) | 0.15 | − 0.14 (− 0.33, 0.04) | 0.13 | − 0.08 (− 0.27, 0.10) | 0.37 |
Synuclein | 353 | − 0.11 (− 0.22, 0.01) | 0.069 | − 0.10 (− 0.21, 0.02) | 0.11 | − 0.08 (− 0.20, 0.04) | 0.21 |
AD-tau | 347 | − 0.15 (− 0.25, − 0.05) | 0.003 | − 0.15 (− 0.25, − 0.05) | 0.004 | − 0.11 (− 0.25, 0.02) | 0.098 |
AGD-tau | 353 | 0.08 (− 0.06, 0.22) | 0.27 | 0.07 (− 0.08, 0.21) | 0.36 | 0.02 (− 0.12, 0.17) | 0.74 |
Association with pTau181-FA | |||||||
Age | 340 | − 0.39 (− 0.52, − 0.25) | < 0.001 | − 0.40 (− 0.54, − 0.26) | < 0.001 | − 0.22 (− 0.34, − 0.10) | < 0.001 |
Sex | 340 | 0.06 (− 0.17, 0.29) | 0.62 | − 0.10 (− 0.32, 0.13) | 0.39 | − 0.07 (− 0.26, 0.12) | 0.45 |
APOE4 | 340 | 0.85 (0.64, 1.07) | < 0.001 | 0.74 (0.53, 0.96) | < 0.001 | 0.28 (0.07, 0.49) | 0.010 |
VaD | 340 | − 0.08 (− 0.32, 0.15) | 0.49 | 0.04 (− 0.19, 0.27) | 0.73 | 0.10 (− 0.10, 0.29) | 0.34 |
CAA | 340 | 0.46 (0.02, 0.90) | 0.041 | 0.44 (0.01, 0.87) | 0.044 | 0.29 (− 0.06, 0.65) | 0.10 |
Neuritic plaque score | 340 | 0.52 (0.44, 0.61) | < 0.001 | 0.49 (0.41, 0.57) | < 0.001 | 0.31 (0.20, 0.42) | < 0.001 |
TDP-43 | 340 | 0.39 (− 0.04, 0.83) | 0.077 | 0.41 (− 0.01, 0.83) | 0.056 | 0.03 (− 0.32, 0.38) | 0.87 |
Synuclein | 340 | 0.35 (0.09, 0.62) | 0.009 | 0.22 (− 0.04, 0.49) | 0.092 | − 0.08 (− 0.30, 0.14) | 0.50 |
AD-tau | 334 | 1.09 (0.89, 1.28) | < 0.001 | 1.00 (0.81, 1.20) | < 0.001 | 0.41 (0.16, 0.66) | 0.002 |
AGD-tau | 340 | − 0.57 (− 0.90, − 0.24) | < 0.001 | − 0.48 (− 0.80, − 0.17) | 0.003 | − 0.08 (− 0.35, 0.19) | 0.57 |