Fig. 6
![Fig. 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs40478-023-01689-5/MediaObjects/40478_2023_1689_Fig6_HTML.png)
Clinical features of 37 brain tumor patients carrying rare POLE or POLD1 germline variants reported in this study or previously (patients and references are listed in the Additional file 1: Table S6). (a) Types of brain tumors observed in patients with rare POLE/POLD1 germline variants. Giant cell glioblastomas are overrepresented. (b) Additional features reported in brain tumor patients with rare POLE/POLD1 germline variants. Gastrointestinal and cutaneous phenotypes are particularly frequent. NOS, not otherwise specified