Fig. 5
![Fig. 5](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs40478-023-01679-7/MediaObjects/40478_2023_1679_Fig5_HTML.png)
Functional identification of MB-R vulnerabilities by HTS. A Distribution of 303 active compounds (5th percentile of all ranked compounds), selected from primary HTS, tested in dose–response experiments, and arranged according to their target/mechanism of action. Each compound is represented as a coloured dot, with increased potency against n MB-R models represented by progressively darker red and increased activity against MB-S cells shown by green color. B Enrichment map summarizing transcriptional GSEA results (p < 0.05) performed in a subset of Gene Set terms (across the C2cp, and C5bp MsigDB gene set collections) correlated to the antimetabolites function, grouped according to their similarity