Table 8 Odds ratio and 95% confidence intervals (OR and 95% CI) of having moderate or severe BPSD (scored 2/3 versus 0/1, on 0–3 scale), stratified by pathology, in cases with severe ADNC (Braak NFT stages V or VI)
Symptom readout | Severe ADNC only versus control | Severe ADNC + LATE-NC Stg > 1 versus control | Severe ADNC + neocortical LBs versus control | QMPa versus control | ||||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p valueb | OR (95% CI) | p valueb | OR (95% CI) | p valueb | OR (95% CI) | p valueb | |
CDR-Global | 10.3 (4.8–23.8) | < 10−6 | 18.1 (7.8–46.3) | < 10−6 | 44.4 (12.6–202.2) | < 10−6 | 37.2 (9.2–204.7) | 0.000003 |
CDR-Language | 7.0 (2.6–21.0) | 0.002 | 7.1 (2.5–22.8) | 0.0005 | 21.7 (5.8–95.2) | 0.00001 | 21.4 (5.0–109.0) | 0.00007 |
NPI-Q: Psychosisc | 7.0 (2.3–26.2) | 0.015 | 18.0 (5.8–71.1) | 0.000004 | 21.3 (5.5–98.0) | 0.00002 | 50.6 (11.3–294.2) | 0.000001 |
NPI-Q: Agitation | 3.4 (1.5–7.5) | 0.027 | 4.2 (1.9–9.8) | 0.0005 | 3.5 (1.1–11.1) | 0.035 | 13.3 (3.6–55.1) | 0.0001 |
NPI-Q: Depression | 2.4 (1.2–5.0) | 0.013 | 1.7 (0.8–3.9) | 0.18 | 2.6 (0.8–8.0) | 0.091 | 7.4 (2.2–26.8) | 0.002 |
NPI-Q: Anxiety | 2.0 (1.0–4.1) | 0.049 | 3.9 (1.8–8.7) | 0.0005 | 2.8 (1.0–8.1) | 0.051 | 15.8 (4.3–76.7) | 0.0001 |
NPI-Q: Apathy | 4.2 (2.1–8.7) | 0.00008 | 6.5 (3.0–14.5) | 0.000002 | 5.0 (1.7–14.9) | 0.003 | 10.0 (2.9–38.9) | 0.0004 |
NPI-Q: Disinhibition | 5.0 (2.2–12.2) | 0.0002 | 6.6 (2.0–16.9) | 0.00004 | 4.7 (1.4–15.6) | 0.01 | 13.0 (3.5–53.3) | 0.0002 |
NPI-Q: Irritability | 4.3 (2.1–9.3) | 0.0001 | 2.1 (0.8–5.0) | 0.11 | 2.6 (0.8–8.0) | 0.11 | 18.2 (5.1–79.1) | 0.00002 |
NPI-Q: Motor | 6.1 (2.1–20.0) | 0.001 | 17.2 (5.8–61.8) | 0.000002 | 14.2 (3.8–59.7) | 0.0001 | 23.1 (5.5–112.1) | 0.00003 |
NPI-Q: Appetite | 1.3 (0.6–2.8) | 0.52 | 1.4 (0.6–3.3) | 0.40 | 3.5 (1.1–11.3) | 0.032 | 0.4 (0–2.4) | 0.42 |