Fig. 5
Clusters of protein changes. a Graphia Professional representation of proteomic abundance data across differentially vulnerable synaptic populations. Each sphere represents a single protein and the edge represents how similar their abundance trend is towards the other proteins in the dataset. The closer the spheres are the more similar the abundance trend. The colours represent the different clusters formed by grouping proteins with similar abundance trends. The resulting profiles were grouped into four different categories as shown in the example graphical abundance trends for further analysis. The annotation associated with each graph represents the cluster numbers which fit each trend and the number of associated proteins. Graphs b-e show the top pathway changes in the clusters indicated