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Table 1 Demographic, clinical (time point 1, 2 & 3) and post-mortem characteristics

From: Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration

 

CTL

AD

Time point

1

2

3

1

2

3

No.

15

12

4

57

57

32

Age, years

86 [79, 87]

88 [83, 90]

90 [89, 95]

83 [77, 88]

84 [78, 89]

87 [79, 89]

Gender, M/F

6/9

7/5

3/1

22/35

22/35

11/21

MMSE

29 [28.5, 30]

29 [28, 30]

29 [28, 29.3]

17 [9, 22]

14 [6, 20]

8 [4, 15]

APOE, ε4 carriers

5/14 (36%)

5/12 (42%)

2/4 (50%)

33/54 (61%)

33/54 (61%)

19/32 (59%)

NfL, pg/mL

29 [23, 34.5]

33 [29.3, 47]

39.3 [33, 45]

42 [33, 57]

48.3 [32, 67]

65 [47.3, 87]

Time to post-mortem, years

7 [3, 8]

7 [4, 8]

6.5 [6, 8]

4 [3, 6]

3 [2, 5]

2 [1, 3]

Braak staging

Transentorhinal (I/II)

8

7

3

2

2

0

Limbic (III/IV)

4

3

0

11

11

4

Isocortical (V/VI)

3

2

1

44

44

28

  1. MMSE was found to be lower among CTL subjects, as compared to AD, across all three time points (p < 0.001)
  2. Plasma NfL was higher among AD subjects, relative to controls, at time point 1 (p < 0.01) and at both second and third time points (p < 0.05)