CTL | AD | ||||||
---|---|---|---|---|---|---|---|
Time point | 1 | 2 | 3 | 1 | 2 | 3 | |
No. | 15 | 12 | 4 | 57 | 57 | 32 | |
Age, years | 86 [79, 87] | 88 [83, 90] | 90 [89, 95] | 83 [77, 88] | 84 [78, 89] | 87 [79, 89] | |
Gender, M/F | 6/9 | 7/5 | 3/1 | 22/35 | 22/35 | 11/21 | |
MMSE | 29 [28.5, 30] | 29 [28, 30] | 29 [28, 29.3] | 17 [9, 22] | 14 [6, 20] | 8 [4, 15] | |
APOE, ε4 carriers | 5/14 (36%) | 5/12 (42%) | 2/4 (50%) | 33/54 (61%) | 33/54 (61%) | 19/32 (59%) | |
NfL, pg/mL | 29 [23, 34.5] | 33 [29.3, 47] | 39.3 [33, 45] | 42 [33, 57] | 48.3 [32, 67] | 65 [47.3, 87] | |
Time to post-mortem, years | 7 [3, 8] | 7 [4, 8] | 6.5 [6, 8] | 4 [3, 6] | 3 [2, 5] | 2 [1, 3] | |
Braak staging | Transentorhinal (I/II) | 8 | 7 | 3 | 2 | 2 | 0 |
Limbic (III/IV) | 4 | 3 | 0 | 11 | 11 | 4 | |
Isocortical (V/VI) | 3 | 2 | 1 | 44 | 44 | 28 |