Spine morphology distribution [%] | |||
---|---|---|---|
Stubby | Thin | Mushroom | |
9w pi CT100 in P7 floxed GluN1 | |||
Control (23) | 0.29 [0.26–0.31] | 0.62 [0.6–0.67] | 0.09 [0.47–0.11] |
CT100 (6) | 0.36 [0.27–0.4] | 0.59 [0.54–0.64] | 0.06 [0.04–0.09] |
GluN1−/− (10) | 0.29 [0.23–0.35] | 0.6 [0.57–0.7] | 0.07 [0.05–0.1] |
GluN1−/− + CT100 (23) | 0.27 [0.23–0.32] | 0.64 [0.62–0.67] | 0.07 [0.05–0.11] |
Kruskal Wallis test (Dunn’s posttest) | P = 0.1972 (Control vs CT100: p = 0.4813 Control vs GluN1−/: p > 0.9999; GluN1−/− vs GluN1−/− + CT100: p > 0.9999) | P = 0.1433 (Control vs CT100: p = 0.6288; Control vs GluN1−/: p > 0.9999; GluN1−/− vs GluN1−/− + CT100: p = 0.5863) | P = 0.8439 (Control vs CT100: p > 0.9999; Control vs GluN1−/: p > 0.9999; GluN1−/− vs GluN1−/− + CT100: p > 0.9999) |
DG granule cells GluN1−/− line | |||
Control (49) | 0.32 [0.27–0.36] | 0.61 [0.54–0.64] | 0.08 [0.05–0.10] |
CT100(I716F) (19) | 0.29 [0.27–0.33] | 0.63 [0.59–0.66] | 0.08 [0.06–0.08] |
GluN1−/− (22) | 0.32 [0.26–0.39] | 0.56 [0.49–0.64] | 0.1 [0.06–0.14] |
GluN1−/− + CT100(I716F) (28) | 0.32 [0.27–0.37] | 0.61 [0.55–0.67] | 0.07 [0.05–0.85] |
Kruskal Wallis test (Dunn’s posttest) | p = 0.529 (Control vs CT100(I716F): p = 0.53; Control vs GluN1−/−: p > 0.9999; GluN1−/− vs GluN1−/− + CT100(I716F): p > 0.9999) | p = 0.198 (Control vs CT100(I716F): p = 0.5339; Control vs GluN1−/−: p = 0.8345; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.3877) | p = 0.1098 (Control vs CT100(I716F): p > 0.9999; Control vs GluN1−/−: p = 0.2132; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.0511) |
DG granule cells GluN2Afl/fl line | |||
Control (11) | 0.35 [0.32–0.37] | 0.57 [0.53–0.62] | 0.08 [0.03–0.11] |
CT100(I716F) (17) | 0.36 [0.29–0.38] | 0.57 [0.52–0.62] | 0.07 [0.06–0.11] |
GluN2A−/− (26) | 0.38 [0.34–0.42] | 0.54 [0.49–0.58] | 0.1 [0.06–0.18] |
GluN2A−/− + CT100(I716F) (21) | 0.34 [0.3–0.38] | 0.55 [0.52–0.61] | 0.1 [0.08–0.13] |
Kruskal Wallis test (Dunn’s posttest) | p = 0.1208 (Control vs CT100(I716F): p > 0.999; Control vs GluN1−/−: p = 0.9455; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.0586) | p = 0.2321 (Control vs CT100(I716F): p > 0.9999; Control vs GluN1−/−: p = 0.2893; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.7813) | p > 0.1487 (Control vs CT100(I716F): p > 0.9999; Control vs GluN1−/−: p > 0.9999; GluN1−/− vs GluN1−/− + CT100(I716F): p = 0.4372) |
DG granule cells GluN2Bfl/fl line | |||
Control (31) | 0.36 [0.33–0.42] | 0.55 [0.49–0.58] | 0.08 [0.06–0.11] |
CT100(I716F) (45) | 0.32 [0.28–0.4] | 0.59 [0.53–0.6442] | 0.07 [0.05–0.1] |
GluN2B−/− (29) | 0.33 [0.28–0.39] | 0.56 [0.49–0.6] | 0.11 [0.09–0.14] |
GluN2B−/− + CT100(I716F) (16) | 0.37 [0.33–0.44] | 0.57 [0.5–0.6] | 0.07 [0.04–0.09] |
Kruskal Wallis test (Dunn’s posttest) | P = 0.0105 (Control vs CT100(I716F): p = 0.0277; Control vs GluN2B−/−: p = 0.043; GluN2B−/− vs GluN2B−/− + CT100(I716F): p = 0.1063) | P = 0.0319 (Control vs CT100(I716F): p = 0.0112; Control vs GluN2B−/−: p = 0.6837; GluN2B−/− vs GluN2B−/− + CT100(I716F): p > 0.9999) | P = 0.0002 (Control vs CT100(I716F): p > 0.9999; Control vs GluN2B−/−: p = 0.0066; GluN2B−/− vs GluN2B−/− + CT100(I716F): p = 0.0048) |