Table 11 Overview of values for spine morphology in 5xFAD mice

 WT (17)

0.31 [0.25–0.34]

0.6 [0.56–0.64]

0.1 [0.06–0.1]

 5xFAD (18)

0.32 [0.27–0.35]

0.58 [0.56–0.61]

0.1 [0.09–0.11]

 Mann-Whitney test

p = 0.4

p = 0.142

p = 0.85

 WT (29)

0.26 [0.22–0.35]

0.64 [0.6–0.7]

0.08 [0.04–0.11]

 5xFAD (28)

0.32 [0.23–0.38]

0.59 [0.23–0.38]

0.09 [0.06–0.16]

 Mann-Whitney test

p = 0.32

p = 0.13

p = 0.14

 GluN1^−/− (7)

0.32 [0.27–0.39]

0.56 [0.45–0.62]

0.12 [0.12–0.16]

 5xFAD/GluN21^−/− (12)

0.29 [0.25–0.31]

0.57 [0.47–0.63]

0.14 [0.12–0.21]

 Mann-Whitney test

p = 0.16

p = 0.526

p = 0.29

 GluN2A^−/− (12)

0.31 [0.24–0.36]

0.58 [0.47–0.64]

0.13 [0.09–0.17]

 5xFAD/GluN2A^−/− (10)

0.39 [0.32–0.5]

0.39 [0.29–0.46]

0.19 [0.14–0.26]

 Mann-Whitney test

p = 0.02

p = 0.002

p = 0.025

 GluN2B^−/− (15)

0.35 [0.27–0.4]

0.53 [0.45–0.62]

0.1 [0.08–0.14]

 5xFAD/GluN2B^−/− (11)

0.42 [0.34–0.52]

0.47 [0.37–0.54]

0.13 [0.1–0.16]

 Mann-Whitney test

p = 0.0362

p = 0.0687

p = 0.3565