| Case status (5 readers per case) | Pathology | | |
---|
Reference standard | TN | FP | FN | TP | Normal | Abnormal | Sensitivitya
| Specificityb
|
mCERADSOT
c
| 131 | 19 | 33 | 347 | 30 | 76 | 91% | 87% |
mCERADmode
d
| 134 | 26 | 30 | 340 | 32 | 74 | 92% | 84% |
CERADe
| 134 | 51 | 30 | 315 | 37 | 69 | 91% | 72% |
Amyloid phasef
| 108 | 2 | 56 | 364 | 22 | 84 | 87% | 98% |
-
TN true negative, FP false positive, FN false negative, TP true positive
-
asensitivity (true positive rate) = TP/(TP + FN)
-
bspecificity (true negative rate) = TN/(TN + FP)
-
cAbnormal defined as any regional mCERADSOT score > 1.5). Note while these analyses are presented by individual reads, the a priori analysis was by majority read (sensitivity was 91% and specificity was 90% by majority read N = 106)
-
dAbnormal defined as any CERAD region moderate or frequent (multiple measures)
-
eAbnormal defined as and CERAD region moderate or frequent (single point estimate)
-
fAbnormal defined as phase 3, 4 or 5