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Table 2 Simultaneous equation regression model of the direct and total effects of age and years of exposure to RHI on CD68 cell density and tau pathology (AT8 tau density)

From: Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy

 

Standardized direct effects

Standardized total effects

Effect/Std error/t value/p value

Effect/Std error/t value/p value

CD68 Density

AT8 Tau Density

CD68 Density

AT8 Tau Density

Age

−0.0195

0.5125

0.006044

0.5136

0.1003

0.0682

0.1009

0.0691

−0.1948

7.5184

0.0599

7.4306

0.8456

<.0001

0.9523

<.0001

RHI Exposure (Years)

0.3911

0.4614

0.4178

0.5349

0.0852

0.071

0.0917

0.0681

4.5911

6.4999

4.5551

7.8586

<.0001

<.0001

<.0001

<.0001

CD68 Density

 

0.1759

 

0.1774

0.0499

 

0.0507

3.5271

 

3.5005

<.0001

 

<.0001

AT8 Tau Density

0.0498

 

0.0503

 

0.0112

0.0114

 

4.4363

4.4058

 

<.0001

<.0001

 
  1. Simultaneous equation regression was used to analyze the direct and total effects. Bolded numbers represent significant p values. Visual pathway analysis can be found in Fig. 2