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Table 1 MtDNA variants identified from sequencing the non-coding region of mtDNA using the Ion Torrent PGM on 12 cell lines representative of GBM

From: The identification of mitochondrial DNA variants in glioblastoma multiforme

   

Percentage change in variant (%)

 

Reference position

Reference

Variant

HSR-GBM1

GBM L1

GBM L2

GBM 4

GBM 6

CSC 014

CSC 020

NO7 152

SF-767

U87MG

HK301

BAH1

Gene region

16186

C

C/T

4.5

           

D loop - Hypervariable segment 1, 7S DNA, membrane attachment site

16218

C

C/T

16.9

           

16224

T

T/C

         

77.9

  

16519

T

T/C

    

53.7

   

55.8

58.2

51.2

52.9

D loop - 7S DNA, membrane attachment site

194

C

T/C

   

4.1

        

D loop - Hypervariable segment 2, membrane attachment site

302

A

A/C

 

16.4

   

41.5

 

39.9

    

310

T

T/C

 

5.6

5.0

  

17.5

 

6.0

    

1386

T

T/C

9.9

           

12s rRNA

2002

G

G/A

    

11.1

       

16s rRNA

2130

A

A/G

 

3.9

5.5

4.0

 

3.6

6.3

7.4

    

2817

G

G/A

           

11.7

3168

C

C/T

    

3.7

    

3.7

  

5752

A

A/G

 

11.3

13.1

11.4

 

10.5

10.9

9.9

    

L strand replication origin

  1. Variants represent those that arise at a percentage frequency of or greater than 3%, after strict parameters were applied to exclude low quality reads from the final mapping of each full mitochondrial genome sequence. Variants that have not been previously reported are in bold.